GO analysis showed that the biological functions of the target genes mainly included activation of receptors, including the nuclear receptor, steroid hormone receptor, acetylcholine receptor, G-protein coupled serotonin receptor, serotonin receptor and others. Results: Our analyses identified 34 target genes that contribute to the development of GC.
Hub genes were identified by protein-protein interaction (PPI) network and then verified by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. GO and KEGG enrichment analyses were used to detect the potential mechanisms of RA targets. GC-related genes were downloaded from GeneCard website. Methods: The Traditional Chinese Medicine System Pharmacology database was used to obtain the chemical components and target genes of RA. Jiubo Fan 1, Hui Jiang 2, Li Sun 3, Qin Zhang 4, Haiju Liu 5ġ Department of Clinical Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China Ģ Department of Clinical Laboratory, Xiangyang Maternal and Child Health Hospital, Xiangyang, China ģ Department of Medical and Technology Laboratory, Medicine of Xiangyang Vocational and Technical College, Xiangyang, China Ĥ Department of Clinical Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China ĥ Department of Outpatient Office, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, ChinaĬontributions: (I) Conception and design: H Liu (II) Administrative support: J Fan, Q Zhang (III) Provision of study materials or patients: J Fan, H Jiang (IV) Collection and assembly of data: L Sun (V) Data analysis and interpretation: J Fan, Q Zhang (VI) Manuscript writing: All authors (VII) Final approval of manuscript: All authors.īackground: The aim of this study was to predict the target genes and pathways of Rhizoma alismatis (RA) in the treatment of gastric cancer (GC) by an bioinformatics analysis.
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